内容摘要：By adding mefloquine to the mix, doctors might be able to reduce the dose of aminoglycosides needed. That would mean fewer side effects, which could open the door for longer and safer treatment. Even more importantly, mefloquine could help ribosomes produce full-length dystrophin—the key protein missing in DMD. Restoring this protein could improve muscle strength and slow disease progression.

By adding mefloquine to the mix, doctors might be able to reduce the dose of aminoglycosides needed. That would mean fewer side effects, which could open the door for longer and safer treatment. Even more importantly, mefloquine could help ribosomes produce full-length dystrophin—the key protein missing in DMD. Restoring this protein could improve muscle strength and slow disease progression.

in Las Vegas in May.Her sleek dress featured a tuxedo-inspired silhouette equipped with a plunging neckline that revealed her cleavage, strong shoulders and notch lapels. The tailored design cascaded into a floor-length skirt complete with a high-front slit.

Rapp let the red-carpet look speak for itself, opting for only a dainty ring and silver earrings. She tied her look together with pointed-toe heels.She donned a full beat at the awards, rocking black eyeliner, brown eyeshadow and pink lips. Her platinum blonde hair was parted to the side and styled in a blowout.The “Not My Fault” singer is proof that if you’ve got it, flaunt it.

to Gianfranco Ferré and, Dior’s legacy is one of the utmost beauty and refinement. Now, UBS House of Craft has partnered with the atelier to connect the designs of all seven creative directors in a single show unlike ever before. Curated by iconic fashion stylist and editor Carine Roitfeld and photographed by Brigitte Niedermair, the exhibit examines the intricate and historic craft of couture through a uniquely modern lens.

The project offered Roitfeld personal access to the archives, where she explored eight decades of history and hand-selected iconic looks—ranging from an eclectic spring 2015 couture minidress by Raf Simons to a extraordinarily chic crocodile jacket from fall 1960 couture by Yves Saint Laurent. “It was a lot of work, but a lot of fun. And because we know the house very well, both of us, we have a nexus to everything we want,” Roitfeld tells ELLE.

The curated archive was then photographed by Niedermair, a longtime collaborator of the house (who has also shot for ELLE.) Through her lens, each piece transcends its original era and is brought into the editorial light of the present day. Adds Roitfeld, “We learned so many things. And even though we are very respectful, we still had some freedom. It was very important for Brigitte and me to have some freedom for the picture.”Frosty Swirls, which launched on the app on April 11 and in stores on April 15, add a twist of sauce to the customer’s choice of a vanilla or chocolate Frosty. Fans can choose strawberry, caramel or brownie batter sauce to make the dessert their own.

The release of Frosty Fusions came around a month later, with the sweet treat arriving at locations nationwide on May 12. Frosty Fusions blend the sauces available for Swirls, with the addition of mix-in toppings.Customers can now order Pop-Tarts Strawberry Frosty Fusion, which is swirled with strawberry sauce and chunks of strawberry Pop-Tarts Crunchy Poppers, marking the toaster pastry’s first time being offered as a frozen dessert mix-in, a previous press release stated.

The Oreo Brownie Frosty Fusion is also available, consisting of a brownie batter sauce and Oreo cookie pieces, combined with a chocolate or vanilla base.Ice cream lovers can also order the Caramel Crunch Frosty Fusion, which adds toffee pieces and caramel sauce to the classic Frosty base.