内容摘要：Mr Hughes says: "One week we could be making a couple of million Covid vaccines, the next week we could be making a couple of million norovirus vaccines. It's that level of flexibility.

Mr Hughes says: "One week we could be making a couple of million Covid vaccines, the next week we could be making a couple of million norovirus vaccines. It's that level of flexibility.

But a US tariff of 10% on Chinese imports has come into effect, after a deadline of 00:01 EST (05:00 GMT) on Tuesday passed.Shortly after, Beijing announced it was imposing retaliatory tariffs on a raft of American products, including 15% on coal and liquefied natural gas and 10% on crude oil and agricultural machinery.

Trump earlier said he planned to speak on the phone to his Chinese counterpart soon. He described the 10% import taxes as the "opening salvo" and said they could become "very, very substantial" if no agreement is made.Monday's breakthrough with Canada and Mexico came as they prepared retaliatory tariffs on American goods.After two phone calls on Monday, Trump and Trudeau posted on social media that they had reached a temporary agreement on securing the border that would avoid tariffs for at least 30 days.

Both leaders portrayed the plan as a win."As president, it is my responsibility to ensure the safety of ALL Americans, and I am doing just that. I am very pleased with this initial outcome," Trump wrote on his social media site Truth Social.

Trudeau said Canada was implementing a $1.3bn (£1bn) border plan that included nearly 10,000 frontline workers and more resources to halt the flow of fentanyl, a synthetic drug 50 times stronger than heroin, which Trump has cited as a major concern.

The prime minister also said Canada would appoint a "fentanyl czar" and launch a joint strike force with the US to combat crime, fentanyl and money laundering.Pepfar was launched in 2003 by then US President George W Bush and its funding is distributed via the US government's main overseas aid agency USAID.

It has been regarded as a ground-breaking scheme that has enabled some of the world's poorest people to access anti-retroviral drugs (ARVs) and has saved more than 25 million lives worldwide.A 90-day freeze on US foreign aid payments instituted by President Donald Trump on his first day in office last month has already upended the global aid system.

In reaction to the raft of cuts, the head of the Africa Centres for Disease Control and Prevention (Africa CDC) issued a stark warning on Friday."I have to say that the world is playing with fire," Dr Jean Kaseya told the BBC.